Is a Critical Regulator for Hematopoietic Stem Cells and Transformed Leukemic Cells
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چکیده
منابع مشابه
Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells.
Evi-1 has been recognized as one of the dominant oncogenes associated with murine and human myeloid leukemia. Here, we show that hematopoietic stem cells (HSCs) in Evi-1-deficient embryos are severely reduced in number with defective proliferative and repopulating capacity. Selective ablation of Evi-1 in Tie2(+) cells mimics Evi-1 deficiency, suggesting that Evi-1 function is required in Tie2(+...
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